PEG linkers, with their unique properties, have been widely used in targeted protein degraders (TPD), including PROTAC, DAC, and LYTAC. As evidenced by current literature [1], a significant proportion of the documented PROTAC constructs leverage PEGs as their linkers of choice due to their unique properties:
- Optimized Solubility and Permeability: The integration of PEG enhances water solubility and cellular permeability, directly influencing the bioavailability of degraders.
- Customizable Length for Enhanced Efficiency: A wide selection of PEG linkers with various lengths to optimize the degradation efficiency of the degraders.
- Rapid Diversification for Accelerated Screening: Hetero-functional PEG linkers equipped with multiple connecting groups can facilitate the swift assembly of a broad spectrum of molecules, expediting the discovery of degrader structures.
Committed to the principle of “Leading the Biomedical Innovation with Material Innovation,” JenKem Technology shows respect for and readiness to aid in your innovative endeavors for protein degradation and targeted protein degradation studies.
- Laboratory Synthesis to Large Scale GMP Manufacturing with Flexibility to Meet Customers’ Specifications
- Certified ISO 13485, ISO 9001, ISO 45001, ISO 14001, ISO 50001 and ISO 27001
- Linker Synthesis Services
- Catalogue Monodisperse PEGs and PEG Linker Products
- PEG Linker Screening
- Custom Synthesis and Analysis Methods Development
- Quality Studies for Clinical Studies
- IND-Related Services
Several monodisperse PEG linkers for PROTAC, DAC, LYTAC applications are listed below and many others are available by custom synthesis. Please contact us for a quotation.
| Item Code | Application |
| NH2-PEGn-PA (n=2-24) | Linker for ADC, PROTAC, DAC and LYTAC |
| AZIDE-PEGn-NH2 (n=2-24) | Linker for ADC, PROTAC, DAC and LYTAC |
| AZIDE-PEGn-PA (n=2-24) | Linker for ADC, PROTAC, DAC and LYTAC |
| ALKYNE-PEGn-SPA (n=2-24) | Linker for ADC, PROTAC, DAC and LYTAC |
| ALKYNE-PEGn-NH2 (n=2-24) | Linker for ADC, PROTAC, DAC and LYTAC |
| M-PEGn-PA (n=2-24) | Linker for ADC, PROTAC, DAC and LYTAC |
| M-PEGn-NH2 (n=2-24) | Linker for ADC, PROTAC, DAC and LYTAC |
| PA-PEGn-PA (n=2-24) | Linker for ADC, PROTAC, DAC and LYTAC |
| MAL-PEGn-PA (n=2-24) | ADC Linker |
| MAL-PEGn-SPA (n=2-24) | ADC Linker |
| DBCO-PEGn-PA (n=2-24) | ADC Linker |
| MAL-PEGn-VC-PAB (n=2-24) | ADC Linker |
| MAL-PEGn-VA-PAB (n=2-24) | ADC Linker |
| DBCO-PEGn-VC-PAB (n=2-24) | ADC Linker |
| DBCO-PEGn-VA-PAB (n=2-24) | ADC Linker |
| (S,R,S)-AHPC hydrochloride | Linker for PROTAC and DAC |
| 4-Hydroxy-thalidomide | Linker for PROTAC and DAC |
| Pomalidomide | Linker for PROTAC and DAC |
| (S,R,S)-AHPC-PEGn-PA (n=2-8) | Linker for PROTAC and DAC |
| (S,R,S)-AHPC-PEGn-NH2 (n=2-8) | Linker for PROTAC and DAC |
| (S,R,S)-AHPC-PEGn-AZIDE (n=2-8) | Linker for PROTAC and DAC |
| (S,R,S)-AHPC-PEGn-ALKYNE (n=2-8) | Linker for PROTAC and DAC |
| Thalidomide-O-PEGn-PA (n=2-8) | Linker for PROTAC and DAC |
| Thalidomide-O-PEGn-SPA (n=2-8) | Linker for PROTAC and DAC |
| Thalidomide-O-PEGn-PAtBu (n=2-8) | Linker for PROTAC and DAC |
| Thalidomide-O-PEGn-NH2 (n=2-8) | Linker for PROTAC and DAC |
| Thalidomide-O-PEGn-AZIDE (n=2-8) | Linker for PROTAC and DAC |
| Thalidomide-O-AMIDO-PEGn-AZIDE (n=2-8) | Linker for PROTAC and DAC |
| Thalidomide-O-PEGn-ALKYNE (n=2-8) | Linker for PROTAC and DAC |
| Thalidomide-O-AMIDO-PEGn-ALKYNE (n=2-8) | Linker for PROTAC and DAC |
| Pomalidomide-PEGn-PA (n=2-8) | Linker for PROTAC and DAC |
| Pomalidomide-PEGn-Ph-NH2 (n=2-8) | Linker for PROTAC and DAC |
| Pomalidomide-PEGn-AZIDE (n=2-8) | Linker for PROTAC and DAC |
References:
[1] Troup RI, Fallan C, Baud MGJ. Current strategies for the design of PROTAC linkers: a critical review. Explor Target Antitumor Ther. 2020;1:273-312.
Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.