JenKem Technology offers large scale GMP manufacture of PEG derivatives for copper-catalyzed and copper-free Click Chemistry.
Kilogram scale manufacture (5Kg per batch and more) of PEG and Monodisperse PEG Azide Derivatives with high purity (95%), in both GMP and non-GMP grade is not available.
PEG azide derivatives are suitable as click chemistry reagents for reaction with alkynes. Click chemistry has found widespread application in bioconjugation in the pharmaceutical and biotech industry. Click reactions are rapid, quantitative, have high efficiency and stereo selectivity, and few or no by-products under mild reaction conditions.
Several examples of scaled-up PEG azide products are listed below, and other products with may be made-to-order. Please contact us at sales@jenkemusa.com for more information.
|
Item Number |
Molecular Weight Range |
| M-PEGn-AZIDE | Monodisperse PEG (n = 6 to 24 or higher) |
| M-PEG-AZIDE | 1000Da-20KDa |
| AZIDE-PEG-SCM | 2000Da-20KDa |
| AZIDE-PEG-NH2TFA | 2000Da-20KDa |
| 4ARM-PEG-AZIDE | 5000Da-40KDa |
| 8ARM(TP)-PEG-AZIDE | 10KDa-40KDa |
In addition to PEG Azides and PEG Alkynes, JenKem Technology is specialized in large scale manufacture of PEG products for Copper-Free Click Chemistry.
JenKem Technology’s PEG DBCO derivatives have good water solubility compared to cyclooctynes, and better biocompatibility and no cytotoxicity as compared to traditional click reagents. JenKem Technology has increased its capability to provide high quality PEG Dibenzocyclooctyne (DBCO) products in large kilogram-scale and above, in both non-GMP and GMP grade, at very affordable prices. 
Below are several examples of PEG DBCO products manufactured by JenKem Technology. PEG and monodisperse PEG DBCO derivatives with different branching, MW, and functionalities may be available by custom synthesis.
Methoxy PEG DBCO Products
| Item Number | Item Description |
| M-DBCO-2000 | Methoxy PEG Dibenzocyclooctyne, MW 2000 |
| M-DBCO-3500 | Methoxy PEG Dibenzocyclooctyne, MW 3500 |
| M-DBCO-5000 | Methoxy PEG Dibenzocyclooctyne, MW 5000 |
| M-DBCO-10K | Methoxy PEG Dibenzocyclooctyne, MW 10000 |
| M-DBCO-20K | Methoxy PEG Dibenzocyclooctyne, MW 20000 |
| M-DBCO-30K | Methoxy PEG Dibenzocyclooctyne, MW 30000 |
| M-DBCO-40K | Methoxy PEG Dibenzocyclooctyne, MW 40000 |
Y-Shaped and U-Shaped PEG DBCO Products
| Item Number | Item Description |
| Y-DBCO-40K | Y-shape (MPEG20K)2 Dibenzocyclooctyne, MW 40000 |
| MPEG2-DBCO-40K | MPEG2 Dibenzocyclooctyne, MW 40000 |
Homobifunctional PEG DBCO Products
| Item Number | Item Description |
| DBCO-PEG2000-DBCO | PEG (Dibenzocyclooctyne)2, MW 2000 |
| DBCO-PEG5000-DBCO | PEG (Dibenzocyclooctyne)2, MW 5000 |
| DBCO-PEG10K-DBCO | PEG (Dibenzocyclooctyne)2, MW 10000 |
Multi-arm PEG DBCO Products
| Item Number | Item Description |
| 4ARM-DBCO-10K | 4arm PEG Dibenzocyclooctyne (pentaerythritol), MW 10000 |
| 4ARM-DBCO-20K | 4arm PEG Dibenzocyclooctyne (pentaerythritol), MW 20000 |
| 8ARM(TP)-DBCO-10K | 8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 10000 |
| 8ARM(TP)-DBCO-20K | 8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 20000 |
| 8ARM(TP)-DBCO-40K | 8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 40000 |
Heterobifunctional PEG DBCO Products
| Item Number | Item Description |
| DBCO-PEG2000-SCM | Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 2000 |
| DBCO-PEG3500-SCM | Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 3500 |
| DBCO-PEG5000-SCM | Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 5000 |
| DBCO-PEG2000-NH2TFA | Dibenzocyclooctyne PEG Amine, TFA Salt, MW 2000 |
| DBCO-PEG3500-NH2TFA | Dibenzocyclooctyne PEG Amine, TFA Salt, MW 3500 |
| DBCO-PEG5000-NH2TFA | Dibenzocyclooctyne PEG Amine, TFA Salt, MW 5000 |
| DBCO-PEG2000-MAL | Dibenzocyclooctyne PEG Maleimide, MW 2000 |
| DBCO-PEG3500-MAL | Dibenzocyclooctyne PEG Maleimide, MW 3500 |
| DBCO-PEG5000-MAL | Dibenzocyclooctyne PEG Maleimide, MW 5000 |
| DBCO-PEG2000-OH | Dibenzocyclooctyne PEG Hydroxyl, MW 2000 |
| DBCO-PEG3500-OH | Dibenzocyclooctyne PEG Hydroxyl, MW 3500 |
| DBCO-PEG5000-OH | Dibenzocyclooctyne PEG Hydroxyl, MW 5000 |
| DBCO-PEG2000-OPSS | Dibenzocyclooctyne PEG OPSS, MW 2000 |
| DBCO-PEG3500-OPSS | Dibenzocyclooctyne PEG OPSS, MW 3500 |
| DBCO-PEG5000-OPSS | Dibenzocyclooctyne PEG OPSS, MW 5000 |
Please contact us at sales@jenkemusa.com for a quotation and more information about our PEG products for Copper-Free Click Chemistry and to inquire about related products not mentioned on this page.
Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.