JenKem Technology provides high purity monodisperse PEG raw materials and monodisperse PEG derivatives with an extensive variety of functional groups, from gram to 15 kilogram batch size or larger in both non-GMP and GMP grade. JenKem Technology’s monodisperse PEG products consist of linear chains of up to 108 –CH2-CH2-O– units (MW ~ 5000Da).
JenKem Technology’s monodisperse PEG products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers. The majority of our high quality monodisperse (discrete) PEG products have purity >98% with <1% highest single impurity.
JenKem Technology provides GMP grade discrete PEG derivatives via custom synthesis, offering the opportunity to match customers’ special quality requirements. The company is ISO 9001 and ISO 13485 certified and follows ICH Q7 guidelines for GMP manufacture.
JenKem Technology offers many monodisperse PEG linkers for antibody drug conjugates (ADCs) and PEG linkers for PROTAC drugs with high purity, in large commercial scale, in both GMP and non-GMP grade.
PEG Linkers for ADCs
Product Name | Molecular Weight |
---|---|
NH2-PEG2-PA | 177.2 |
NH2-PEG3-PA | 221.3 |
NH2-PEG4-PA | 265.3 |
NH2-PEG6-PA | 353.4 |
NH2-PEG7-PA | 397.5 |
NH2-PEG8-PA | 441.5 |
NH2-PEG9-PA | 485.6 |
NH2-PEG10-PA | 529.6 |
NH2-PEG11-PA | 573.7 |
NH2-PEG12-PA | 617.7 |
NH2-PEG24-PA | 1146.4 |
NH2-PEG8-CM | 427.5 |
NH2-PEG12-CM | 603.7 |
NH2-PEG24-CM | 1132.3 |
DBCO-PEG2-PA | 464.5 |
DBCO-PEG3-PA | 508.6 |
DBCO-PEG4-PA | 552.6 |
DBCO-PEG6-PA | 640.7 |
DBCO-PEG8-PA | 728.8 |
DBCO-PEG10-PA | 816.9 |
DBCO-PEG12-PA | 905.0 |
DBCO-PEG24-PA | 1433.7 |
DBCO-PEG8-CM | 714.8 |
DBCO-PEG12-CM | 891.0 |
DBCO-PEG24-CM | 1419.7 |
DBCO-PEG8-NH2 | 655.8 |
DBCO-PEG12-NH2 | 832.0 |
DBCO-PEG24-NH2 | 1360.6 |
MAL-PEG2-PA | 328.3 |
MAL-PEG3-PA | 372.4 |
MAL-PEG4-PA | 416.4 |
MAL-PEG6-PA | 504.5 |
MAL-PEG8-PA | 592.6 |
MAL-PEG12-PA | 768.9 |
MAL-PEG24-PA | 1297.5 |
MAL-PEG2-SPA | 425.4 |
MAL-PEG4-SPA | 513.5 |
MAL-PEG6-SPA | 601.6 |
MAL-PEG8-SPA | 689.7 |
MAL-PEG12-SPA | 865.9 |
MAL-PEG24-SPA | 1394.6 |
MAL-PEG8-CM | 578.6 |
MAL-PEG12-CM | 754.8 |
MAL-PEG24-CM | 1283.5 |
AZIDE-PEG4-NH2 | 218.3 |
AZIDE-PEG12-NH2 | 570.7 |
AZIDE-PEG24-NH2 | 1099.3 |
AZIDE-PEG4-PA | 291.3 |
AZIDE-PEG12-PA | 643.7 |
AZIDE-PEG24-PA | 1172.4 |
AZIDE-PEG12-CM | 629.7 |
AZIDE-PEG24-CM | 1158.3 |
ALKYNE-PEG8-SPA | 577.6 |
ALKYNE-PEG12-SPA | 753.8 |
HO-PEG4-ALKYNE | 232.3 |
DBCO-PEG4-VC-PAB | 914.1 |
DBCO-PEG6-VC-PAB | 1002.2 |
DBCO-PEG8-VC-PAB | 1090.3 |
DBCO-PEG12-VC-PAB | 1266.5 |
DBCO-PEG24-VC-PAB | 1795.1 |
DBCO-PEG4-VA-PAB | 828.0 |
DBCO-PEG6-VA-PAB | 916.1 |
DBCO-PEG8-VA-PAB | 1004.2 |
DBCO-PEG12-VA-PAB | 1180.4 |
DBCO-PEG24-VA-PAB | 1709.0 |
MAL-PEG4-VC-PAB | 777.9 |
MAL-PEG6-VC-PAB | 866.0 |
MAL-PEG8-VC-PAB | 954.1 |
MAL-PEG12-VC-PAB | 1130.3 |
MAL-PEG24-VC-PAB | 1658.9 |
MAL-PEG4-VA-PAB | 691.8 |
MAL-PEG6-VA-PAB | 779.9 |
MAL-PEG8-VA-PAB | 868.0 |
MAL-PEG12-VA-PAB | 1044.2 |
MAL-PEG24-VA-PAB | 1572.8 |
Please contact us to inquire about our large-scale manufacture capabilities for these PEGs for ADCs.
PEG Linkers for PROTAC Applications
JenKem Technology provides high-purity PROTAC PEG linkers with various active groups and a range of E3 ligase ligands and E3 ligase ligand-linker conjugates to assist with your PROTAC-related projects.
Product Name | CAS No. |
---|---|
Amino PEG2 Propionic Acid | 791028-27-8 |
Amino PEG3 Propionic Acid | 784105-33-5 |
Amino PEG4 Propionic Acid | 663921-15-1 |
Amino PEG2 Acetic Acid | 134978-97-5 |
Amino PEG3 Acetic Acid | 134978-99-7 |
Amino PEG4 Acetic Acid | 195071-49-9 |
Hydroxyl PEG4 Amine, HCl Salt | 86770-74-3 |
Hydroxyl PEG3 Azide | 86520-52-7 |
Azido-PEG3-Acetic Acid | 172531-37-2 |
Azido-PEG4-Propionic Acid | 1257063-35-6 |
Alkyne PEG5 Propionic Acid | 1951438-84-8 |
Alkyne PEG6 Amine, HCl Salt | 1589522-46-2 |
Propionic Acid PEG5 Propionic Acid | 119189-70-7 |
Please contact us to inquire about our large-scale manufacture capabilities for these PEG linkers for PROTACs.
E3 Ligase Ligand-Linker Conjugates
Product Name | CAS No. |
---|---|
(S,R,S)-AHPC PEG2 Propionic Acid | 2172820-09-4 |
(S,R,S)-AHPC PEG4 Propionic Acid | 2172820-12-9 |
(S,R,S)-AHPC PEG6 Propionic Acid | |
(S,R,S)-AHPC PEG2 Amine, HCl Salt | 2010159-60-9 |
(S,R,S)-AHPC PEG4 Amine, HCl Salt | 2010159-57-4 |
(S,R,S)-AHPC PEG4 Azide | |
(S,R,S)-AHPC PEG5 Alkyne | |
Thalidomide-O PEG4 Propionic Acid | 2353563-50-3 |
Thalidomide-O PEG4 Succinimidyl Propionate | 2411681-88-2 |
Thalidomide-O PEG4 tert-Butyl Propionate | 2411681-87-1 |
Thalidomide-O PEG5 Amine, HCl Salt | 2401832-00-4 |
Thalidomide-O PEG5 Azide | 2380318-57-8 |
Thalidomide-O Amido PEG5 Azide | 2411681-89-3 |
Thalidomide-O PEG4 Alkyne | 2098799-77-8 |
Thalidomide-O Amido PEG4 Alkyne | 2411681-90-6 |
Pomalidomide PEG3 Propionic Acid | |
Pomalidomide PEG4 Phenyl Amine | 1818885-63-0 |
Pomalidomide PEG5 Azide | 2271036-47-4 |
Please contact us to inquire about our large-scale manufacture capabilities for these E3 Ligase Ligands and E3 Ligase Ligand-Linker Conjugates.
Below are some examples of in-stock non-GMP grade monodisperse (discrete) PEG raw materials with high purity (>99%).
Item Number | Item Description |
---|---|
HO-PEG7-OH | Heptaethylene Glycol, MW 326.4 |
HO-PEG8-OH | Octaethylene Glycol, MW 370.4 |
HO-PEG9-OH | Enneethylene Glycol, MW 414.5 |
HO-PEG10-OH | Decaethylene Glycol, MW 458.6 |
HO-PEG11-OH | Undecaethylene Glycol, MW 502.6 |
HO-PEG12-OH | Dodecaethylene glycol, MW 546.7 |
Below are some examples of our monodisperse (discrete) PEG products with purity >98% that have been scaled-up to kilogram scale batch size:
Item Number | Item Description |
---|---|
HO-PEG9-OH | Enneethylene Glycol, MW 414.5 |
HO-PEG10-OH | Decaethylene Glycol, MW 458.6 |
HO-PEG11-OH | Undecaethylene Glycol, MW 502.6 |
HO-PEG12-OH | Dodecaethylene glycol, MW 546.7 |
HO-PEG36-OH | Hexatriacontaethylene Glycol, MW 1603.9 |
M-PEG7-OH | Methoxy PEG7 Hydroxyl, MW 340.4 |
M-PEG11-OH | Methoxy PEG11 Hydroxyl, MW 516.6 |
M-PEG11-PA | Methoxy PEG11 Propionic Acid, MW 588.7 |
Bn-PEG3-OH | Triethylene glycol monobenzyl ether, MW 240.3 |
Bn-PEG4-OH | Tetraethylene glycol monobenzyl ether, MW 284.4 Da |
Bn-PEG6-OH | Benzyl PEG6 Hydroxyl, MW 372.5 Da |
Bn-PEG7-OH | Benzyl PEG7 Hydroxyl, MW 416.5Da |
Please click the buttons below to order catalog items directly from JenKem Technology. Monodisperse PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. For inquiries on custom production of monodisperse PEG derivatives and PEGylation services please contact us at tech@jenkemusa.com. For global distributor information, please visit this link.
MONODISPERSE PEG PRODUCTS | MW | PURITY |
---|---|---|
Various | > 98% | |
252.2 | ≥ 95% | |
296.2 | ≥95% | |
251.4 | ≥95% | |
295.3 | ≥95% | |
324.4 | ≥95% | |
368.2 | ≥95% | |
277.3 | ≥90% | |
321.4 | ≥90% | |
268.4 | ≥90% | |
312.4 | ≥90% | |
306.3 | ≥90% | |
350.4 | ≥90% | |
370.5 | ≥95% | |
414.5 | ≥95% | |
546.7 | ≥95% | |
368.5 | ≥95% | |
544.8 | ≥95% | |
486.5 | ≥95% | |
662.7 | ≥95% | |
514.6 | ≥95% | |
674.8 | ≥95% | |
369.5 | ≥95% | |
545.8 | ≥95% | |
428.5 | ≥95% | |
604.8 | ≥95% | |
442.5 | ≥95% | |
618.8 | ≥95% |
References:
- El-Gogary, R.I., et al., Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo. ACS Nano, 2014, 8(2): p. 1384-1401.
- Zhou, J., et al., In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7): p. 2044-2047.
- Raza, A., et al., Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic. Materials Today Advances, 2022, 13, p.100210.
Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.