JenKem Technology provides high purity monodisperse PEG raw materials and monodisperse PEG derivatives with an extensive variety of functional groups, from gram to 15 kilogram batch size or larger in both non-GMP and GMP grade. JenKem Technology’s monodisperse PEG products consist of linear chains of up to 108 –CH2-CH2-O– units (MW ~ 5000Da).

JenKem Technology’s monodisperse PEG products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers. The majority of our high quality monodisperse (discrete) PEG products have purity >98% with <1% highest single impurity.

JenKem Technology provides GMP grade discrete PEG derivatives via custom synthesis, offering the opportunity to match customers’ special quality requirements. The company is ISO 9001 and ISO 13485 certified and follows ICH Q7 guidelines for GMP manufacture.

JenKem Technology offers many monodisperse PEG linkers for antibody drug conjugates (ADCs) and PEG linkers for PROTAC drugs with high purity, in large commercial scale, in both GMP and non-GMP grade.

PEG Linkers for ADCs

Please contact us to inquire about our large-scale manufacture capabilities for these PEGs for ADCs.

PEG Linkers for PROTAC Applications

JenKem Technology provides high-purity PROTAC PEG linkers with various active groups and a range of E3 ligase ligands and E3 ligase ligand-linker conjugates to assist with your PROTAC-related projects.

Please contact us to inquire about our large-scale manufacture capabilities for these PEG linkers for PROTACs.

E3 Ligase Ligand-Linker Conjugates

Please contact us to inquire about our large-scale manufacture capabilities for these E3 Ligase Ligands and E3 Ligase Ligand-Linker Conjugates.

Below are some examples of in-stock non-GMP grade monodisperse (discrete) PEG raw materials with high purity (>99%).

Below are some examples of our monodisperse (discrete) PEG products with purity >98% that have been scaled-up to kilogram scale batch size:

Please click the buttons below to order catalog items directly from JenKem Technology. Monodisperse PEG products with molecular weights and functional groups not listed in our online catalog may be available by custom synthesis. For inquiries on custom production of monodisperse PEG derivatives and PEGylation services please contact us at tech@jenkemusa.com. For global distributor information, please visit this link.

References:

1. El-Gogary, R.I., et al., Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo. ACS Nano, 2014, 8(2): p. 1384-1401.
2. Zhou, J., et al., In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7): p. 2044-2047.
3. Raza, A., et al., Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic. Materials Today Advances, 2022, 13, p.100210.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.