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Linear Heterobifunctional PEGs
PEG PRODUCT | PURITY | REACTIVITY DETAILS |
---|---|---|
≥95% | Hydroxyl PEG Carboxyl (Hydroxyl PEG Acetic Acid, HO-PEG-CM, HO-PEG-COOH). COOH group is stable and can be activated [1, 2] | |
≥95% | Hydroxyl PEG Succinimidyl Carboxymethyl Ester (HO-PEG-NHS). Crosslinking reagent, the activated form of HO-PEG-COOH [3, 4] | |
≥95% | Hydroxyl PEG Propionic Acid (Hydroxyl PEG Propanoic Acid, HO-PEG-PA). COOH group is stable and can be activated | |
≥95% | Hydroxyl PEG Succinimidyl Propionate (Hydroxyl PEG Succinimidyl Propanoate, HO-PEG-SPA). Crosslinking reagent, the activated form of HO-PEG-PA | |
≥95% | Hydroxyl PEG Amine (HO-PEG-NH2). NH2 group is stable and can be activated [8] | |
≥95% | Thiol PEG Carboxyl (HS-PEG-COOH, Thiol PEG Acetic Acid, HS-PEG-CM). HS is thiol reactive, while COOH is stable and can be activated [5, 6] | |
≥95% | Thiol PEG Succinimidyl Propionate (HS-PEG-SPA). HS is thiol reactive while COOH is stable and can be activated | |
>90% | Thiol PEG Succinimidyl Glutaramide (HS-PEG-SGA). Crosslinking PEG reagent. Longer hydrolysis half-life compared to the SCM NHS PEG ester. [7] | |
≥95% | Thiol PEG Amine (HS-PEG-NH2). HS is thiol reactive and NH2 is stable and can be activated [9] | |
≥95% | Amine PEG Carboxyl (NH2-PEG-COOH). Both COOH and NH2 groups are stable and can be activated [10, 11] | |
≥95% | TBOC Amine PEG Hydroxyl (TBOC-PEG-OH). Crosslinking PEG reagent. Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine [12] | |
≥95% | TBOC Amine PEG Amine (TBOC-PEG-NH2). Crosslinking PEG reagent. Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine [13] | |
≥95% | TBOC Amine PEG Carboxyl (TBOC-PEG-COOH, TBOC-PEG-CM, TBOC PEG Acetic Acid). Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine [15] | |
>90% | TBOC Amine PEG SCM Ester (TBOC-PEG-SCM, TBOC-PEG-NHS, ). Crosslinking PEG for ADC development. Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine [18] | |
>90% | TBOC Amine PEG Succinimidyl Propionate (TBOC-PEG-SPA). Crosslinking PEG for ADC development. Tert-butyloxycarbonyl (Boc) protection group can be removed by treatment with trifluoroacetic acid (TFA) or other common acids to provide a free amine | |
≥95% | FMOC Amine PEG Hydroxyl (FMOC-PEG-OH) Crosslinking PEG reagent. The 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine | |
≥95% | FMOC Amine PEG Amine (FMOC-PEG-NH2). Crosslinking PEG reagent. 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine [14] | |
≥95% | FMOC Amine PEG Carboxyl (FMOC-PEG-COOH, FMOC-PEG-CM, FMOC-PEG-Acetic Acid). The 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine [16, 17] | |
>90% | FMOC Amine PEG NHS Ester (FMOC-PEG-SCM, FMOC-PEG-NHS). The 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine [19] | |
>90% | FMOC Amine PEG Succinimidyl Propionate (FMOC PEG SPA). The 9-fluorenylmethoxycarbonyl (Fmoc) group can be removed by treatment with piperidine to release a free amine [19] | |
>90% | Acrylate PEG NHS Ester (ACLT-PEG-NHS, ACLT-PEG-SCM). Light sensitive PEG, will crosslink with exposure to ultraviolet light [20-22] | |
>90% | Acrylate PEG Succinimidyl Propionate (ACLT-PEG-SPA). Light sensitive PEG, will crosslink with exposure to ultraviolet light | |
≥95% | Maleimide PEG Hydroxyl (MAL-PEG-OH). Maleimide is thiol reactive and Hydroxyl is stable [23] | |
≥95% | Maleimide PEG Amine (MAL-PEG-NH2). Maleimide is thiol reactive and Amine is stable and can be activated [24] | |
≥95% | Maleimide PEG Carboxyl (MAL-PEG-CM, MAL-PEG-COOH). Maleimide is thiol reactive and Carboxyl is stable and can be activated [25] | |
>90% | Maleimide PEG NHS Ester, the activated form of MAL-PEG-COOH [26-31] | |
>90% | Biotin PEG SCM Ester. Biotin can be attached to avidin-containing surfaces or molecules; NHS ester reacts with amine groups [32] | |
≥95% | Biotin PEG Maleimide. Crosslinking reagent for ADC development. Biotin can be attached to avidin-containing surfaces or molecules; Maleimide group is thiol reactive [33] | |
≥95% | Biotin PEG Succinimidyl Glutaramide. Biotin can be attached to avidin-containing surfaces or molecules; SGA has a longer hydrolysis half-life compared with SCM NHS Ester [38] | |
>90% | OPSS PEG NHS Ester. Ortho-pyridyl disulfide (OPSS) is thiol reactive; NHS ester can be reacted with Amine groups [34] | |
>90% | Azide PEG NHS Ester. The Azide group may be reduced to amine by hydrogenolysis; Click chemistry PEG reagent for reaction with alkynes [35] | |
≥95% | Azide PEG Amine. The Azide group may be reduced to amine by hydrogenolysis; Click PEG reagent for reaction with alkynes [36] | |
≥95% | Alkyne PEG Maleimide. Click PEG reagent for reaction with azides [37] |
Monodisperse Discrete Heterobifunctional PEGs
4arm Heterobifunctional PEGs
PEG PRODUCT | FIRST FUNCTIONAL GROUP | SECOND FUNCTIONAL GROUP | SUBSTITUTION |
Methoxy (3) | SCM (1) | ≥ 90% | |
Hydroxyl (1) | Carboxyl (3) | ≥ 95% | |
Hydroxyl (3) | Carboxyl (1) | ≥ 95% | |
Hydroxyl (3) | Amine (1) | ≥ 95% | |
Hydroxyl (3) | t-BOC Protected Amine (1) | ≥ 95% | |
Hydroxyl (2) | Carboxyl (2) | ≥ 95% | |
Hydroxyl (2) | Amine (2) | ≥ 95% | |
8arm Heterobifunctional PEGs
PEG PRODUCT | FIRST FUNCTIONAL GROUP | SECOND FUNCTIONAL GROUP | SUBSTITUTION |
---|---|---|---|
Hydroxyl (7) | Carboxyl (1) | ≥ 95% | |
Hydroxyl (7) | Carboxyl (1) | ≥ 95% |