JenKem Technology now offers large scale GMP manufacture of premium fatty acid side chain products for drug modification, with batch size as high as 10Kg-100Kg, with high purity and good lot-to-lot reproducibility.
Fatty acid side chains are known to aid in improving patient compliance with increased half-life for Glucagon-like peptide-1 (GLP-1) receptor agonists, which are extensively used in the treatment of type II diabetes and obesity. Several drug entities such as tirzepatide, somapacitan, or semaglutide, are modified to incorporate fatty acid side-chains.
Services offered by JenKem Technology:
• Fatty Acid Side-Chain Custom Synthesis
• Customized Molecular Coupling Services (see example poster to the right)
• Characterization of Modified Polypeptide(s) and their Catabolites
• Quality Studies Related to Clinical Studies
The following is a selection of Fatty Acids Side Chains we offer as catalog items, however more can be made-to-order. Please contact us at sales@jenkemusa.com for a quotation for fatty acid side chains and related services.
| Product Name | Purity | CAS No. |
| tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu | ≥98% | 1118767-16-0 |
| Ste-Glu-AEEA-AEEA-OSU | ≥90% | 1169630-40-3 |
| tBuO-Ste-Glu(AEEA-AEEA-OSU)-OtBu | ≥95% | 1118767-15-9 |
| Fmoc-Lys(tBuO-Ste-Glu(AEEA-AEEA)-OtBu)-OH | ≥98% | 1662688-20-1 |
| tBuO-ICO-Glu(AEEA-AEEA-OH)-OtBu | ≥98% | 1188328-37-1 |
| ICO-Glu-AEEA-AEEA-OSU | ≥90% | 1188328-38-2 |
| tBuO-ICO-Glu(AEEA-AEEA-OSU)-OtBu | ≥95% | 1118767-17-1 |
| Fmoc-Lys(tBuO-ICO-Glu(AEEA-AEEA)-OtBu)-OH | ≥98% | 2460751-66-8 |
Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, co-polymers, lipids, fatty acid side chains, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.