JenKem Technology offers large scale GMP manufacture of premium fatty acid side chain products for drug modification, with batch size of 10kg-100kg, with high purity and good lot-to-lot reproducibility. Fatty acid side chains are known to aid in improving patient compliance with increased half-life for Glucagon-like peptide-1 (GLP-1) receptor agonists, which are extensively used in the treatment of type II diabetes and obesity. Several drug entities on the market, such as tirzepatide, somapacitan, or semaglutide, are modified to incorporate fatty acid side-chains [1].
Fatty Acid Side Chain – related products and services offered by JenKem Technology:
- Fatty Acid Side-Chain Custom Synthesis
- Customized Fatty Acid Side-Chain Conjugation Services [2]
- Characterization of Fatty Acid-Conjugated Polypeptide(s) and their Catabolites
- Quality Studies Related to Clinical Studies
The following is a selection of Fatty Acids Side Chains we offer as catalog items and more can be made to order. Please contact us at sales@jenkemusa.com for a quotation for fatty acid side chains and related services.
| Product Name | Purity | CAS No. |
| tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu | ≥98% | 1118767-16-0 |
| Ste-Glu-AEEA-AEEA-OSU | ≥90% | 1169630-40-3 |
| tBuO-Ste-Glu(AEEA-AEEA-OSU)-OtBu | ≥95% | 1118767-15-9 |
| Fmoc-Lys(tBuO-Ste-Glu(AEEA-AEEA)-OtBu)-OH | ≥98% | 1662688-20-1 |
| tBuO-ICO-Glu(AEEA-AEEA-OH)-OtBu | ≥98% | 1188328-37-1 |
| ICO-Glu-AEEA-AEEA-OSU | ≥90% | 1188328-38-2 |
| tBuO-ICO-Glu(AEEA-AEEA-OSU)-OtBu | ≥95% | 1118767-17-1 |
| Fmoc-Lys(tBuO-ICO-Glu(AEEA-AEEA)-OtBu)-OH | ≥98% | 2460751-66-8 |
References:
- Galindo, RJ, et al, Insights into the Mechanism of Action of Tirzepatide: A Narrative Review. Diabetes Ther. 2026;17(1):19-40.
- Yan, S., et al., Dual-Arm Fatty Acid Conjugated Peptides: Structural Optimization and Advantage Exploration, TIDES 2025 Poster Presentation.
Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, co-polymers, lipids, fatty acid side chains, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7 guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.
