Click Chemistry has found widespread application in bioconjugation in the pharmaceutical and biotech industry. Click reactions are rapid, quantitative, have high efficiency and stereo selectivity, and few or no by-products under mild reaction conditions.
JenKem Technology provides numerous PEG Azide and PEG Alkyne derivatives for traditional click chemistry reaction with copper (I), however this reaction has limited use in biomedical applications due to the catalyst’s cytotoxicity. The reaction of azides with strained alkynes, such as cyclooctynes, known as “Copper-Free Click Chemistry“ does not require a toxic metal catalyst, but most of the cyclooctyne reagents do not have good water solubility, which limits their applications in biomedicine.
JenKem Technology’s PEG DBCO derivatives have good water solubility compared to cyclooctynes, and better biocompatibility and no cytotoxicity as compared to traditional click reagents. JenKem Technology has increased its capability to provide high quality PEG Dibenzocyclooctyne (DBCO) products in large kilogram-scale and above, in both non-GMP and GMP grade, at very affordable prices. 
Below are several examples of PEG DBCO products manufactured by JenKem Technology. PEG and monodisperse PEG DBCO derivatives with different branching, MW, and functionalities may be available by custom synthesis.
Methoxy PEG DBCO Products
| Item Number | Item Description |
| M-DBCO-2000 | Methoxy PEG Dibenzocyclooctyne, MW 2000 |
| M-DBCO-3500 | Methoxy PEG Dibenzocyclooctyne, MW 3500 |
| M-DBCO-5000 | Methoxy PEG Dibenzocyclooctyne, MW 5000 |
| M-DBCO-10K | Methoxy PEG Dibenzocyclooctyne, MW 10000 |
| M-DBCO-20K | Methoxy PEG Dibenzocyclooctyne, MW 20000 |
| M-DBCO-30K | Methoxy PEG Dibenzocyclooctyne, MW 30000 |
| M-DBCO-40K | Methoxy PEG Dibenzocyclooctyne, MW 40000 |
Y-Shaped and U-Shaped PEG DBCO Products
| Item Number | Item Description |
| Y-DBCO-40K | Y-shape (MPEG20K)2 Dibenzocyclooctyne, MW 40000 |
| MPEG2-DBCO-40K | MPEG2 Dibenzocyclooctyne, MW 40000 |
Homobifunctional PEG DBCO Products
| Item Number | Item Description |
| DBCO-PEG2000-DBCO | PEG (Dibenzocyclooctyne)2, MW 2000 |
| DBCO-PEG5000-DBCO | PEG (Dibenzocyclooctyne)2, MW 5000 |
| DBCO-PEG10K-DBCO | PEG (Dibenzocyclooctyne)2, MW 10000 |
Multi-arm PEG DBCO Products
| Item Number | Item Description |
| 4ARM-DBCO-10K | 4arm PEG Dibenzocyclooctyne (pentaerythritol), MW 10000 |
| 4ARM-DBCO-20K | 4arm PEG Dibenzocyclooctyne (pentaerythritol), MW 20000 |
| 8ARM(TP)-DBCO-10K | 8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 10000 |
| 8ARM(TP)-DBCO-20K | 8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 20000 |
| 8ARM(TP)-DBCO-40K | 8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 40000 |
Heterobifunctional PEG DBCO Products
| Item Number | Item Description |
| DBCO-PEG2000-SCM | Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 2000 |
| DBCO-PEG3500-SCM | Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 3500 |
| DBCO-PEG5000-SCM | Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 5000 |
| DBCO-PEG2000-NH2 | Dibenzocyclooctyne PEG Amine, Free amine, MW 2000 |
| DBCO-PEG3500-NH2 | Dibenzocyclooctyne PEG Amine, Free amine, MW 3500 |
| DBCO-PEG5000-NH2 | Dibenzocyclooctyne PEG Amine, Free amine, MW 5000 |
| DBCO-PEG2000-MAL | Dibenzocyclooctyne PEG Maleimide, MW 2000 |
| DBCO-PEG3500-MAL | Dibenzocyclooctyne PEG Maleimide, MW 3500 |
| DBCO-PEG5000-MAL | Dibenzocyclooctyne PEG Maleimide, MW 5000 |
| DBCO-PEG2000-OH | Dibenzocyclooctyne PEG Hydroxyl, MW 2000 |
| DBCO-PEG3500-OH | Dibenzocyclooctyne PEG Hydroxyl, MW 3500 |
| DBCO-PEG5000-OH | Dibenzocyclooctyne PEG Hydroxyl, MW 5000 |
| DBCO-PEG2000-OPSS | Dibenzocyclooctyne PEG OPSS, MW 2000 |
| DBCO-PEG3500-OPSS | Dibenzocyclooctyne PEG OPSS, MW 3500 |
| DBCO-PEG5000-OPSS | Dibenzocyclooctyne PEG OPSS, MW 5000 |
JenKem Technology has the capability for custom manufacture of other PEG products for copper-free click chemistry not listed here. Please contact us at sales@jenkemusa.com for a quotation and more information about our PEG products for Copper-Free Click Chemistry.
JenKem Technology specializes in the development and manufacture of high-quality polyethylene glycol (PEG) derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back integrated to in-house polymerization from ethylene oxide to ensure batch to batch reproducibility. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.